Associated Structures
Accession: P02724 UniProtKB/Swiss-Prot Entry
UniProtKB/Swiss-Prot PTM Description
The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific)
Glycosylation Sites
Position | Structures | Description | Evidence |
---|---|---|---|
Associated Structures: 6 | global | GlycoSuite |
Position | Structures | Description | Evidence |
---|---|---|---|
Associated Structures: 2 | global | GlycoSuite |
Position | Structures | Description | Evidence |
---|---|---|---|
SER-21, THR-22, THR-23, THR-29, SER-30, THR-31, SER-32, THR-36, SER-38, SER-41, THR-44, ASN-45, THR-52, THR-56, SER-63, SER-66, THR-69 | Associated Structures: 13 | global | GlycoSuite |
Position | Structures | Description | Evidence |
---|---|---|---|
SER-21, THR-22, THR-23, THR-29, SER-30, THR-31, SER-32, THR-36, SER-38, SER-41, THR-44, ASN-45, THR-52, THR-56, SER-63, SER-66, THR-69 | Associated Structures: 4 | global | GlycoSuite |
Notes
Accompanying information sourced from GlycoSuiteDB
- SER-21, THR-22, THR-23, THR-29, SER-30, THR-31, SER-32, THR-36, SER-38, SER-41, THR-44, ASN-45, THR-52, THR-56, SER-63, SER-66 & THR-69 [PISANO ET AL. (1993) GLYCOBIOLOGY 3:429-435
- SER-21, THR-22, THR-23, THR-29, SER-30, THR-31, SER-32, THR-36, SER-38, SER-41, THR-44, ASN-45, THR-52, THR-56, SER-63, SER-66 AND THR-69 [PISANO ET AL. (1993) GLYCOBIOLOGY 3:429-435
Sequence
Biological Associations
References showing top 5 7
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A carbohydrate structural variant of MM glycoprotein (glycophorin A).
PubMed: 6619126 Year: 1983
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PubMed: 3967649 Year: 1985
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Primary structure of the oligosaccharide determinant of blood group Cad specificity.
PubMed: 6190803 Year: 1983
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PubMed: 8384526 Year: 1993
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Membrane glycophorins in Sta blood group erythrocytes.
PubMed: 3514617 Year: 1986
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Structures of the asparagine-linked sugar chains of glycophorin A.
PubMed: 7430095 Year: 1980
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