Associated Structures
Accession: P00743 UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot PTM Description
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium, N- and O-glycosylated, The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway), The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains
Glycosylation Sites
Position | Structures | Description | Evidence |
---|---|---|---|
THR-208, ASN-218, THR-485 | Associated Structures: 11 | global | GlycoSuite |
Site-Specific Information
A number of glycan structures have been assigned to specific glycosylation sites
Position | Structures | Description | Evidence |
---|---|---|---|
ASN-218 | Associated Structures: 2 | Site specific | GlycoSuite |
Notes
Accompanying information sourced from GlycoSuiteDB
- THR-208 [INOUE AND MORITA (1993) EUR. J. BIOCHEM. 218:156-163
- ASN-218 & THR-485 [TITANI ET AL. (1975) PNAS 72:3082-3086
Sequence
MAGLLHLVLLSTALGGLLRPAGSVFLPRDQAHRVLQRARRANSFLEEVKQGNLERECLEEACSLEEAREVFEDAEQTDEFWSKYKDGDQCEGHPCLNQGHCKDGIGDYTCTCAEGFEGKNCEFSTREICSLDNGGCDQFCREERSEVRCSCAHGYVLGDDSKSCVSTERFPCGKFTQGRSRRWAIHTSEDALDASELEHYDPADLSPTESSLDLLGLNRTEPSAGEDGSQVVRIVGGRDCAEGECPWQALLVNEENEGFCGGTILNEFYVLTAAHCLHQAKRFTVRVGDRNTEQEEGNEMAHEVEMTVKHSRFVKETYDFDIAVLRLKTPIRFRRNVAPACLPEKDWAEATLMTQKTGIVSGFGRTHEKGRLSSTLKMLEVPYVDRSTCKLSSSFTITPNMFCAGYDTQPEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIDKIMKARAGAAGSRGHSEAPATWTVPPPLPL