UniProtKB/Swiss-Prot PTM Description

Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is N-glycosylated and processed likely by host cell furin or by a furin-like protease in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R

Glycosylation Sites

Position Structures Description Evidence
ASN-12, ASN-168, ASN-266, THR-268, SER-273, SER-275, THR-277, THR-279, ASN-302, ASN-334, ASN-341, ASN-374, ASN-410 Associated Structures: 52 global GlycoSuite
Site-Specific Information

A number of glycan structures have been assigned to specific glycosylation sites

Position Structures Description Evidence
ASN-334 AND/OR ASN-341 Associated Structures: 3 Site specific GlycoSuite
ASN-12 Associated Structures: 8 Site specific GlycoSuite
ASN-168 Associated Structures: 1 Site specific GlycoSuite
ASN-302 Associated Structures: 8 Site specific GlycoSuite
ASN-410 Associated Structures: 1 Site specific GlycoSuite
THR-268, SER-273, SER-275, THR-277, THR-279 AND THR-304 AND/OR THR-309 Associated Structures: 2 Site specific GlycoSuite
ASN-12 AND ASN-334 AND/OR ASN-341 Associated Structures: 4 Site specific GlycoSuite
ASN-168, ASN-334 AND/OR ASN-341 AND ASN-410 Associated Structures: 1 Site specific GlycoSuite
ASN-266, ASN-302, ASN-334 AND/OR ASN-341, ASN-374 AND ASN-410 Associated Structures: 24 Site specific GlycoSuite

Notes

Accompanying information sourced from GlycoSuiteDB

  1. ASN-12, ASN-168, ASN-266, THR-268, SER-273, SER-275, THR-277, THR-279, ASN-302, THR-304 &/OR THR-309, ASN-334, ASN-341, ASN-374 & ASN-410 [GEYER ET AL. (1990) EUR. J. BIOCHEM. 187:95-110

Sequence

AAPGSSPHQVYNITWEVTNGDRETVWAISGNHPLWTWWPVLTPDLCMLALHGPPHWGLEYQAPYSSPPGPPCCSGSGGSSPGCSRDCNEPLTSLTPRCNTAWNRLKLDQVTHKSSEGFYVCPGSHRPREAKSCGGPDSFYCASWGCETTGRAYWKPSSSWDYITVDNNLTTNQAVQVCKDNKWCNPLAIQFTNAGRQVTSWITGHYWGLRLYVSGQDPGLTFGIRLKYQNLGPRVPIGPNPVLADQLSFPLPNPLPKPAKSPPVSNSTPTMISPSPTPTQPPPAGTGDRLLNLVQGAYQALNLTNPDKTQECWLCLVSGPPYYEGVAVLGTYSNHTSAPTNCSVASQHKLTLSEVTGRGLCIGTVPKTHQALCNTTLKTNKGSYYLVAPAGTTWACNTGLTPCLSATVLNRTTDYCVLVELWPRVTYHPPSYVYSQFEKSYRHKR

References 2

  1. Oligosaccharides at individual glycosylation sites in glycoprotein 71 of Friend murine leukemia virus.

    Geyer R, Dabrowski J, Dabrowski U, Linder D, Schlter M, Schott H, Stirm S

    PubMed: 2298213 Year: 1990

  2. Glycosylation of the envelope glycoprotein from a polytropic murine retrovirus in two different host cells.

    Geyer H, Kempf R, Schott H, Geyer R

    PubMed: 2174368 Year: 1990