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Development and validation of an automated and marker-free CT-based spatial analysis method (CTSA) for assessment of femoral hip implant migration In vitro accuracy and precision comparable to that of radiostereometric analysis (RSA)

This publication appears in: Acta Orthopaedica

Authors: T. Scheerlinck, M. Polfliet, R. Deklerck, G. Van Gompel, N. Buls and J. Vandemeulebroucke

Volume: 87

Issue: 2

Pages: 139-145

Publication Date: Apr. 2016


Abstract:

Background and purpose - We developed a marker-free automated CT-based spatial analysis (CTSA) method to detect stem-bone migration in consecutive CT datasets and assessed the accuracy and precision in vitro. Our aim was to demonstrate that in vitro accuracy and precision of CTSA is comparable to that of radiostereometric analysis (RSA). Material and methods - Stem and bone were segmented in 2 CT datasets and both were registered pairwise. The resulting rigid transformations were compared and transferred to an anatomically sound coordinate system, taking the stem as reference. This resulted in 3 translation parameters and 3 rotation parameters describing the relative amount of stem-bone displacement, and it allowed calculation of the point of maximal stem migration. Accuracy was evaluated in 39 comparisons by imposing known stem migration on a stem-bone model. Precision was estimated in 20 comparisons based on a zero-migration model, and in 5 patients without stem loosening. Results - Limits of the 95% tolerance intervals (TIs) for accuracy did not exceed 0.28?mm for translations and 0.20° for rotations (largest standard deviation of the signed error (SDSE): 0.081?mm and 0.057°). In vitro, limits of the 95% TI for precision in a clinically relevant setting (8 comparisons) were below 0.09?mm and 0.14° (largest SDSE: 0.012?mm and 0.020°). In patients, the precision was lower, but acceptable, and dependent on CT scan resolution. Interpretation - CTSA allows detection of stem-bone migration with an accuracy and precision comparable to that of RSA. It could be valuable for evaluation of subtle stem loosening in clinical practice.

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Prof. Dr. Ir. Rudi Deklerck

+32 (0)02 629 168

rdeklerc@etrovub.be

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Prof. Dr. Ir. Jef Vandemeulebroucke

+32 (0)02 629 103

jefvdmb@etrovub.be

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