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A Novel Micro-step Separation Device for the Size Separation of Cells This publication appears in: Electrophoresis Authors: S. Vankrunkelsven, D. Clicq, K. Pappaert, W. Ranson, C. De Tandt, H. Ottevaere, H. Thienpont, G. Baron and G. Desmet Volume: 25 Issue: 10-11 Pages: 1714-1722 Publication Year: 2004
Abstract: We report on a series of preliminary experiments investigating the applicability of a novel method for the size separation of nano- and microsized particles and cells. The working principle is based on the application of a shear-driven flow through stepwise tapered micro- or nanochannels. Size separations of mixtures of 0.5 and 1.0 microm carboxylated polystyrene beads as well as of binary mixtures of Staphylococcus aureus and Saccharomyces cerevisiae cells and of S. cerevisiae and Escherichia coli cells are demonstrated.
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